РОМЕО Эрик Томас (US),МАШАСЕК Мишелль Р. (US),ТРОТТЕР Бенджамин Уэсли (US),МИЛЛЕР Томас Аллен (US),АНДРЕСЕН Брайан Майкл (US),ЭНТОНИ Невилл Джон (US),ТАОКА Брендон М. (US),ЛЮ Юань (US)
申请号：
RU2013153540/04
公开号：
RU2013153540A
申请日:
2012.04.30
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R is selected from the group consisting of: (i) -C-C1-6 alkyl； (ii) fluoroalkyl； (iii) -CHOR, where R is selected from the group consisting of H and C- C1-6 alkyl； (iv) -N (R), where each R is selected from the group consisting of H and C-C1-6 alkyl, or two R together with the N atom to which they are attached form a group of the formula where r is 1, 2, 3 or 4； (v) -O- (C-C1-6 alkyl)； (vi) -N (H) C (0) - (C-C1-6 alkyl)； (vii) halogen； (viii) H； and (ix) morpholinyl； R is —OH, —O— (C-C1-6 alkyl), —N (R), —N (R) C (O) —R or —F； where each R is selected from the group consisting of H and C-C1-6 alkyl； and R 1 is C-C 1-6 alkyl； R 1 is -COR, -CHCOR, -CHCHCOR, tetrazole, -C (O) N (R), -CHOH, H, halogen, -OH, C-C 1-6 alkyl, -O- (C 1 -C 6 alkyl ), -N (R), -CN, -C (O) N (H) S (O) R, -C (O) -N (H) (R), -C (O) N (H) C (O) R, -P (O) (OR) or -B (OH)； where R is selected from the group consisting of H and C-C1-6 alkyl； where each R is independently selected from the group consisting of H and C-C1-6 alkyl； where R is selected from the group consisting of C-C1-6 alkyl, C-C-fluoroalkyl, C-Cycloalkyl and phenyl, wherein said phenyl is unsubstituted or substituted with one or two C-C1-6alkyls； where R is selected from the group consisting of -CN, -O- (C -Salkyl) and tetrazole； R is -COR, -CHCOR, -CHCHCOR, tetra ol, -C (O) N (R), -CHOH, H, halogen, -OH, C-C1-6alkyl, -O- (C-C1-6alkyl), -N (R), -CN, -C (O) N (H) S (O) R, -C (O) -N (H) (R), -C (O) N (H) C (O) R, -P (O) (OR) or -B ( OH)； where R is selected from the group consisting of H and C-C1-6 alkyl； where each R is independently selected from the group consisting of H and C-C1-6 alkyl； where R is selected from the group consisting of C-C-alkyl, CC-fluoroalkyl, C- Cycloalkyl and phenyl, wherein said phenyl is unsubstituted or substituted with one or two CC alkyls； where R is selected from the group consisting of —CN, —O— (C-C1-6 alkyl) and tetrazole
