PROBLEM TO BE SOLVED: To provide novel therapeutic means of advanced recurrent colon cancer which cannot be excised.SOLUTION: This invention relates to a therapeutic agent of colon cancer obtained by a combination of an anti-PROK1 antibody and an anti-VEGF antibody, and the therapeutic agent obtained by a further combination of at least one anticancer agent selected from irinotecan, cetuximab, 5-fluorouracil, oxaliplatin and panitumumab.COPYRIGHT: (C)2015,JPO&INPIT【課題】切除不能な進行再発大腸癌の新規治療手段を提供する。【解決手段】抗PROK1抗体と抗VEGF抗体とを組み合わせてなる、大腸癌の治療剤。イリノテカン、セツキシマブ、5-フルオロウラシル、オキサリプラチン及びパニツムマブから選択される少なくとも1種の抗癌剤を、さらに組み合わせてなる、該治療剤。【選択図】なし
