Sandra van Wetering,Tanja Denise de Gruijl,Adriane Marie Kruisbeek,Rieneke van de Ven,Riekeld Johannes Scheper
申请号：
US12736920
公开号：
US08470789B2
申请日:
2008.11.12
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a method for the production of functional dendritic cells wherein CD34 positive cells are contacted with compounds inducing and accelerating the differentiation of these CD34 positive cells into functional dendritic cells. More in particular, the CD34 positive cells are contacted with anthracyclines and/or anthracenediones. In another aspect, the current invention relates to the cells obtainable by the method according to the invention. In a further aspect the current invention relates to the use of compounds such as anthracyclines and/or anthracenediones that induce and accelerate the differentiation of CD34 positive cells into functional dendritic cells in the manufacture of a medicament for inducing an immune response in human in need thereof.
