Aspects of the invention include methods of treating withdrawal syndrome by applying a transdermal delivery device containing a dexmedetomidine composition formulated to deliver a non-sedative amount of dexmedetomidine to a subject diagnosed as having withdrawal syndrome. In practicing methods according to certain embodiments, a transdermal delivery device having a dexmedetomidine composition is applied to a subject and is maintained in contact with the subject in a manner sufficient to deliver a non-sedative amount of dexmedetomidine to treat withdrawal syndrome in the subject. Also provided are transdermal delivery devices configured to deliver a non-sedative amount of dexmedetomidine sufficient for practicing the subject methods, as well as kits containing the transdermal delivery devices.本發明之特徵係包括藉由施予一包含經調配用以遞送一非鎮靜量右美托咪啶(dexmedetomidine)之右美托咪啶組成物的經皮遞送裝置給經診斷患有戒斷症候群的患者,來治療戒斷症候群之方法。在根據特定實施例之施行方法中,係將具有右美托咪啶組成物之經皮遞送裝置施予一患者並且以足以遞送一鎮靜量右美托咪啶來治療患者中之戒斷症候群的方式保持與患者接觸。亦提供經配置用以遞送一足夠施行主題方法之非鎮靜量右美托咪啶的經皮遞送裝置,以及包含此經皮遞送裝置之套組。