1. A medicine for the therapeutic treatment and / or improvement of sepsis, which contains thrombomodulin as an active ingredient, characterized in that the drug is administered to a patient with severe sepsis, accompanied by dysfunctions of one or more organs, where the value of the international normalized ratio (INR ) in a plasma sample obtained from the specified patient, exceeds 1.4.2. The medicament according to claim 1, characterized in that the medicament is administered to a patient with severe sepsis, accompanied by dysfunctions of one or more organs, where the value of the international normalized ratio (INR) in the plasma sample obtained from the specified patient exceeds 1.4 and is equal to or less than 1.6.3. The medicament according to claim 1 or 2, wherein the patient with severe sepsis is a patient with severe sepsis in which organ dysfunction is not limited to liver or kidney dysfunctions. A medicament according to claim 1 or 2, wherein said medicament is administered to a patient with severe sepsis accompanied by dysfunctions of one or more organs selected from the group consisting of liver dysfunction, renal dysfunction, respiratory dysfunction and circulatory dysfunction. The medicament according to claim 1 or 2, wherein said medicament is administered to a patient with severe sepsis accompanied by dysfunctions of one or more organs selected from the group consisting of respiratory dysfunction and circulatory dysfunction. A medicament according to claim 1 or 2, characterized in that thrombomodulin is a soluble throm1. Лекарственное средство для терапевтического лечения и/или улучшения состояния при сепсисе, которое содержит тромбомодулин в качестве активного ингредиента, отличающееся тем, что указанное лекарственное средство вводят пациенту с тяжелым сепсисом, сопровождающимся дисфункциями одного или более органов, где значение международного нормализованного отношения (INR) в образце плазмы, полученном от указанного пациента, превышает 1,4.2. Л
