(57)< Abstract > Approximately, being blood congestion removal medicine formulation which possesses the action duration under 16 hours, and 1 day 1 single oral administration units which include the anti- histamine medicine, the said blood congestion removal medicine is the pseudo ephedrine or phenyl propanol amine, is something where the said anti- histamine medicine does not have quiet action, action duration of the said blood congestion removal medicine formulation is approximately 16 hours from approximately 10 hours, action duration of the said anti- histamine formulation is approximately 24 hours, the single oral administration unit is offered. In addition, being the method of drawing up the single oral administration unit in order to remedy the nasitis, process, and to said formulation which to formulation it converts the anti- histamine medicine of the quantity which possesses the action duration which is longer than as many as approximately 22 hours the process which to formulation it converts the blood congestion removal medicine of the quantity which possesses the action duration under approximately 16 hours in the person, in the person the blood congestion removal medicine and to said formulation of the quantity which is converted mixing the anti- histamine medicine of the quantity which is converted, the method of including the process which it makes the single oral administration unit is offered.約16時間未満の作用持続時間を有する鬱血除去薬製剤、及び抗ヒスタミン薬を含む1日1回の単一経口投与単位であって、該鬱血除去薬がプソイドエフェドリン又はフェニルプロパノールアミンであり、該抗ヒスタミン薬が鎮静作用を持たないものであり、該鬱血除去薬製剤の作用持続時間が約10時間から約16時間であり、該抗ヒスタミン製剤の作用持続時間が約24時間である、単一経口投与単位が提供される。また、鼻炎を治療するための単一経口投与単位を作成する方法であって、ヒトにおいて約16時間未満の作用持続時間を有する量の鬱血除去薬を製剤化する工程、ヒトにおいて約22時間よりも長い作用持続時間を有する量の抗ヒスタミン薬を製剤化する工程、及び該製剤化された量の鬱血除去薬及び該製剤化された量の抗ヒスタミン薬を混合して単一の経口投与単位とする工程を含む方法が提供される。
