Monospecific and bispecific human monoclonal antibodies targeting insulin-like growth factor II (IGF-II)

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专利权人:

发明人:

Dimiter S. Dimitrov,Weizao Chen,Yang Feng

申请号：

US14352312

公开号：

US09127056B2

申请日:

2012.10.16

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Monoclonal antibodies (mAbs), antigen binding fragments and engineered antibody domains (eAds) that specifically bind IGF-II are disclosed herein. In some embodiments, these mAbs and eAds are included in a bispecific mAb. In some embodiments, the bispecific antibody specifically binds two different epitopes of IGF-II. Methods of using these mAbs, antigen binding fragments, and eAds, bispecific antibodies, and nucleic acids encoding these mAbs, antigen binding fragments, and eAds, bispecific antibodies are also disclosed.

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