ГУ Цзицзе (US),ХАТЧИНС Чарльз В. (US),ЧЖУ Жун-Жун (US),ШЭНЬ Цзяньвэй (US),ХАРРИС Мария С. (US),БИЛЕНДЖЕР Эйлин (US),МУРТАЗА Анвар (US),ТАРКСА Эдит (US),СТАЙН Улльям Б. (US),ХСИЕХ Чунг-минг (US)
申请号：
RU2011104228/10
公开号：
RU2011104228A
申请日:
2009.07.08
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A binding protein or fragment thereof capable of binding prostaglandin E2 (PGE2) containing:! (a) at least one CDR containing SEQ ID NO: 6, 7, 8, 10, 11, 12, 14, 15, 16, 18, 19, 20, 22, 23, 26, 27, 28, 30 , 31, 32, 34, 35, 37, 38, 39, 54, 55, 56, 57, 58, or 59； ! (b) at least one CDR containing the amino acid sequence of at least about 60%, at least about 65%, at least about 70%, at least about 75%, at least about 80%, at least about 85%, at least about 90%, at least about 95%, or at least about 98% homologous to SEQ ID NO: 54, 55, 56, 57, 58 or 59； and / or! (c) at least one VH region containing SEQ ID NO: 5, 13, 21, 25, 33, 40, 42, 44, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78 or 80； and / or! (d) at least one VL region containing SEQ ID NO: 9, 17, 24, 29, 36, 41, 43, 45, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79 or 81； and / or! (e) an antibody or antigen binding fragment thereof； and / or! - wherein said binding protein or fragment thereof is optionally capable of modulating the biological function of PGE2, neutralizing PGE2 and / or preventing the binding of PGE2 to at least one of its receptors EP1, EP2, EP3 and EP4； and / or! - wherein said binding protein or fragment thereof optionally binds PGE2 in an ELISA with an EC50 of about 1 · 10-6 to 1 · 10-7 M, from 1 · 10-7 to 1 · 10-8 M, from 1 · 10-8 to 1 · 10-9 M, from 1 · 10-9 to 1 · 10-10 M, from 1 · 10-10 to 1 · 10-11 M, from 1 · 10-11 to 1 · 10- 12 M； and / or! - where said binding protein or fragment thereof optionally inhibits the binding of PGE2 to at least one of its E1, E2, E3 or E4 receptors in a cell surface-based receptor binding assay or in a n� receptor binding assay1. Связывающий белок или его фрагмент, способные связывать простагландин E2 (PGE2), содержащие: ! (а) по меньшей мере, одну CDR, содержащую SEQ ID NO: 6, 7, 8, 10, 11, 12, 14, 15, 16, 18, 19, 20, 22, 23, 26, 27, 28, 30, 31, 32, 34, 35, 37, 38, 39, 54, 55, 56, 57, 58 или 59； ! (b) по меньшей мере, одну CDR, содержащую аминокислотную после
