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ORALLY DISINTEGRATING TABLETS AND PROCESS FOR OBTAINING THEM
专利权人:
VITA CIENTIFICA
发明人:
FERRAN JAVIER SEGADO
申请号:
HRP20041158
公开号:
HRP20041158B1
申请日:
2004.12.06
申请国别(地区):
HR
年份:
2012
代理人:
摘要:
The tablets comprise: at least 59.5% spray-dried mannitol; active ingredient below or equal to 10%, where at least 90% in weight of the active ingredient has a particle size below 100 mum; microcrystalline cellulose 10-18%, with an average particle size of 50 mum and where at least 99% in weight of microcrystalline cellulose has a particle size below 250 mum; sodium croscarmellose 14%; and a lubricant agent 0.5-2%; where, unless specified otherwise, the percentages are expressed in weight of the total weight of the tablet. And also a process comprising: sieving and mixing of components except for the lubricant agent; mixing of all components; and direct compression of the final mixture. The tablets of the invention give lower disintegration times as well as good perception on the tongue after disintegration, and overcome the problem of insufficient mechanical resistance for packaging and transport operations.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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