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Anti-CD98 antibody processes
专利权人:
KYOWA HAKKO KIRIN CO.; LTD.
发明人:
Tomoyuki Tahara,Yoshikatsu Kanai,Hitoshi Endou,Shiro Kataoka,Kazumasa Hasegawa,Tetsuya Yoshino
申请号:
US13940640
公开号:
US09051374B2
申请日:
2013.07.12
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A human antibody or a functional fragment thereof having specific binding ability to CD98 which is derived from the cell membrane of cancer cells and is in the form of a complex with a protein having an amino acid transporter activity (for example, LAT1) is disclosed. This antibody binds to CD98 in the form of a dimer with LAT1 on the surface of cancer cells, specifically attacks cancer cells expressing CD98 via the immune system by ADCC or CDC, and further inhibits amino acid uptake of the cancer cells via LAT1, to suppress growth of the cancer cells. Accordingly, a preventive and therapeutic agent for cancer comprising this antibody or a fragment thereof, which acts on various cancers, is specific to cancer, and causes no side effect, is provided.
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