A method is provided to disrupt tau entanglements and amyloid plaques in a persons brain. An ultrasound profile generated by an ultrasound device is applied to the persons brain. The generated ultrasound profile is characterized by a frequency between 20-100 kHz, a pulse power greater than 10 W/cm−2, a pulse length greater than 1 microsecond, and an interval between pulses greater than 1 millisecond. The method is performed without intravenous injection of microbubbles to the person or use of preformed microbubbles.
