Julie Hambleton,Maureen Bleam,Maurice P. DeYoung,Geraldine Ferron-Brady,Rakesh Kumar,Lone Ottesen
申请号：
US15861047
公开号：
US20180280470A1
申请日:
2018.01.03
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods of treating cancers comprising FGFR1 gene amplification, FGFR1 overexpression, FGFR3 overexpression, FGFR3 amplification, FGF2 overexpression, and/or FGF2 gene amplification are provided. In some embodiments, the methods comprise administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule. In some embodiments, the methods comprise administering a FGFR1 ECD and/or an FGFR1 ECD fusion molecule in combination with at least one additional therapeutic agent. In some embodiments, methods of treating cancers comprising administering a FGFR1 ECD and/or an FGFR1 ECD fusion molecule in combination with at least one chemotherapeutic agent are provided.
