Disclosed is a compound of formula I e.g. 2-(1-(6-acetamidopyrimidine-4-carboxamido)ethyl)-N-( 5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-1H-carboxamide or a pharmaceutically acceptable salt thereof, wherein: disorder is selected from a proliferative disorder, a cardiac disorder, a neurodegenerative disorder, an autoimmune disorder, a condition associated with organ transplant, an inflammatory disorder, an immunologically-mediated disorder, a viral disease, or a bone disorder.
