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Novel Block Copolymer, Micelle Preparation, And Anticancer Agent Containing The Same As Active Ingredient
专利权人:
Nippon Kayaku Kabushiki Kaisha
发明人:
Kazuhisa Shimizu,Keizou Ishikawa,Takeshi Nakanishi
申请号:
US13971036
公开号:
US20140024703A1
申请日:
2013.08.20
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A medicinal preparation is desired which has no harmful side effects such as hypersensitive reaction, heightens the water solubility of a sparingly water-soluble anticancer agent, maintains a high drug concentration in the blood, accumulates a drug in a tumor tissue at a high concentration, heightens the pharmacological effect of the sparingly water-soluble anticancer agent, and diminishes the side effects of the anticancer agent. Provided are: a novel block copolymer which can be a drug carrier having no harmful side effects such as hypersensitive reaction; a micelle preparation in which micelles are formed and which contains a sparingly water-soluble anticancer agent, especially paclitaxel, incorporated in the micelles in an amount necessary for a disease treatment without bonding it to the block copolymer and which can heighten the solubility of the drug in water; and an anticancer agent which comprises the micelle preparation as a medical ingredient, maintains a high concentration in the blood, has more potent drug activity, and is reduced in toxicity.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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