腫瘍画像化のためのアミノ酸類似体の立体選択的合成

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专利权人:

エモリー ユニバーシティー

发明人:

グッドマン, マーク エム.,ユー, ウェイピン

申请号：

JP2008518271

公开号：

JP5349960B2

申请日:

2006.06.19

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The radiolabeled non-natural amino acid 1-amino-3-cyclobutane-1-carboxylic acid (ACBC) and its analogs are candidate tumor imaging agents useful for positron emission tomography and single photon emission computed tomography due to their selective affinity for tumor cells. The present invention provides methods for stereo-selective synthesis of syn-ACBC analogs. The disclosed synthetic strategy is reliable and efficient and can be used to synthesize a gram quantity of various syn-isomers of the ACBC analogs, particularly, syn-[¹⁸F]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC) and syn-[¹²³I]-1-amino-3-iodocyclobutane-1-carboxylic (IACBC) acid analogs.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/