The present application discloses a biomaterial having a synergistic effect, a method for manufacturing the same, and a system comprising the same. The biomaterial comprises a bioceramic carrier having a hierarchically meso-macroporous structure and at least silicon and oxygen compositions, nano-scale silver particles confined in the hierarchically meso-macroporous structure which is composed of a wall having a plurality of mesopores and a plurality of macropores, and the wall separates the plurality of macropores, and a bioactivator confined in partial of the mesopores or attached on a surface of the wall. The biomaterial located in a system containing a microorganism and a hydrophilic medium has a synergistic effect and a fractional inhibitory concentration index (FIC index) of less than or equal to 0.5 after a certain period of time.本發明揭示一種具有協同作用之生醫材料，其製造方法及包含此生醫材料之系統。此生醫材料包含一具有多級孔結構之生醫陶瓷載體，其中此生醫陶瓷載體至少含矽和氧成分；一奈米級銀顆粒限域於此多級孔結構，其中此多級孔結構包含一具有複數個介孔之孔壁及複數個巨孔，且此孔壁分隔此複數個巨孔；以及一生物活性劑，其中此生物活性劑限域於部分之此複數個介孔中或附著於此孔壁之一表面。本發明揭示的生醫材料位於一個包含一微生物及一親水性介質的系統中，經過一特定時間後產生協同作用且具有一小於或等於0.5的分率抑菌濃度指數（fractional inhibitory concentration index，FIC index）。
