The invention is characterized in a kind of by cell is contacted the method that suppresses the one or more voltage gated ion channel voltage-gated ion channels in the cell with following material: the passage that (i) first chemical compound, its activation are present on nociceptor and/or the scratchiness receiver forms receptor (ii) second chemical compound, it suppresses described ion channel when putting on the inner surface of one or more voltage-gated ion channels, but do not suppress described passage when putting on the outer surface of described passage basically, wherein, when described receptor was activated, described second chemical compound can form receptor by described passage and enter nociceptor or scratchiness receiver.Feature of the present invention also is quaternary ammonium derivative or other permanent charged or instantaneous charged derivants of chemical compound, described chemical compound suppresses described ion channel when putting on the inner surface of one or more voltage-gated ion channels, but does not suppress described passage when putting on the outer surface of described passage basically.
