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Complex oral formulation comprising omega-3 fatty acid and an HMG CoA reductase inhibitor with improved stability
专利权人:
15
发明人:
JIN CHEUL KIM,JAE HO KIM,EUN JIN YOON,YONG IL KIM,JAE HYUN PARK,JONG SOO WOO
申请号:
ARP120104299
公开号:
AR088876A1
申请日:
2012.11.15
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
1. Claim 1: complex oral formula, including: (1) the core of hard or soft capsule, which contains adsorbent, sorb, as an effective pharmaceutical component, and omega-3 fatty acid; (2) The first layer includes a coating of waterproof coating material, which is formed on the surface of the package box core; the second layer includes a reduced HMG-CoA inhibitor and an alkaline stabilizer,The second coat is formed on the surface of the first coat. Claim 5: a complex oral representation of claim 1, i.e. the omega-3 fatty acid is selected from the natural or synthetic omega-3 fatty acid group; an ester acceptable from a drug, derivative, precursor or precursor salt; and any mixture of the two substances. Claim 7: complex oral representation of claim 5, selected from Eicosapenta-5, 8, 11, 14, 17-enoico acids (Eicosapentanoico, EPA), this Omega-3 fatty acid,Dodoxyethane-4,7,10,13,16,19-phenol acid (dodoxyethane, DHA),And / or a-linoleic acid and precursor. 128. Claim 8: the complex oral representation of claim 1, according to the total weight of the core, the weight of this omega-3 fatty acid varies from 70% to 95%. 110. Claim 10: a complex oral representation of claim 1, wherein the water-resistant coating material comprises ethylene cellulose. Claim 12: a complex oral representation of claim 1, wherein HMG CoA reductase inhibitors are selected from a group consisting of simvastatina, pravastatina, flavastatina, torvastatina, cerivastatina, and rosuvastatina,This is a kind of herbal medicine that can be accepted from the perspective of medicine. Claim 14: for the complex oral statement of claim 1, the above alkali stabilizers are selected from the magnesium carbonate (mgcos 832323) group;1. Sodium carbonate (nahco83323);Magnesium hydroxide (Mg (OH) 832222);Plus the old mix 2. Claim 23: a complex oral representation of claim 1, wherein the second coating comprises a selected set of coating materials, including: ethyl hydroxypropyl cellulose, polyethylene, polyethylene, pol
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