COLLINGWOOD, STEPHEN,MCCARTHY, CLIVE,HARGRAVE, JONATHAN DAVID,HAY, DUNCAN ALEXANDER,SCHOFIELD, THOMAS BEAUREGARD,ELLAM, SARAH,BUXTON, CRAIG,HABGOOD, MATTHEW,INGRAM, PETER,MA, CHUN YAN,NAPIER, SPENCER
申请号：
CA3086747
公开号：
CA3086747A1
申请日:
2019.01.25
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.
