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ANTISEPTIKAHALTIGE SILIKONELASTOMERE
专利权人:
Bayer Healthcare LLC
发明人:
LOHRMANN, Marc,PUDLEINER, Heinz,HYNER, Joachim
申请号:
EP07724282.4
公开号:
EP2016126B1
申请日:
2007.04.17
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
Silicone elastomers (SE) containing a homogeneously dispersed antiseptic with an average particle size (d50) of 0.5-15 (preferably 1-10) microns and a particle size distribution of 0.1-30 (preferably 0.5-20) microns. Independent claims are included for (1) catheters containing SE as above (2) silicone rubber formulations (SRF) containing (A) polysiloxane(s) of formula R 1>(R 2>) 2SiO(SiR 3>R 4>O) xSiR 1>(R 2>) 2 (I), (I) polyhydrogen-siloxane(s) of formula R 21>(R 22>) 2SiO(SiR 23>R 24>O) xSiR 21>(R 22>) 2 (II), (J) catalyst(s) containing a platinum group metal and not more than 3 parts by weight (pts. wt.) other metal compounds (oxides, carbonates, other salts or complexes of Fe, Al, Zn, Ti, Zr, Ce or other lanthanoids) to 100 pts. wt. (A), and (K) at least one suspension of antiseptic(s) (especially chlorhexidine, octenidine, PHMB, Quats, taurolidine and/or triclosan) in (I) and/or (II) and/or non-functional siloxanes (G) (3) a method for the production of SE by polymerising SRF as defined above. R 1>, R 2>1-12C alkyl or fluoroalkyl, or optionally substituted phenyl or naphthyl R 3>, R 4>as for R 1>/R 2>, but also -OSiR 2>R 3>R R : a continuation of the siloxane chain indicating a branch, so that the polymer contains branching units of formula SiO 4/2 and R 3>SiO 3/2 R 1> and R 3>may also be 1-12C alkenyl groups, with the polymer containing 0.0002-3 wt% vinyl groups and at least two olefinic double bonds per molecule x (in (I)) : 2-15000, varied so that the polymer shows a viscosity of 0.1-1000 Pa.s at 25[deg]C R 21>, R 22>as for R 1> and R 2> R 23>H, or other groups as for R 1>/R 2>, or uOSiR 23>R 24>R giving branching units SiO 4/2 and R 23>SiO 3/2 with R 23> = H in at least 4 of these silyldioxy units, so that one molecule has at least 4 crosslinking sites R 24>as for R 23> but not H x (in (II)) : 4-10000, varied to give a viscosity of 0.0005-0.1 Pa.s at 25[deg]C.
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