A method and apparatus for sealing a puncture or incision formed percutaneously in a tissue. The apparatus includes an anchor, a sealing plug, a suture, a compaction member assembly, a spool assembly, and a release member. The compaction member assembly is structured and arranged to apply a compressive force to compact the sealing plug toward the anchor. The spool assembly includes a plurality of post members, and the suture is wound about the post members to define a suture cam path. Unspooling the suture along the suture cam path provides driving of the compaction member assembly. The release member is operable to move the post members to release the suture member from the spool assembly.
