#$%^&*AU2019280071A120200116.pdf#####ABSTRACT: Methods are provided herein for treating mania in mood disorders and other neurological diseases or disorders. The methods provided herein comprise administering a VMAT2 inhibitor to a subject in need thereof. A VMAT2 inhibitor 5 useful in the methods provided herein includes (S)-2-Amino-3-methyl-butyric acid (2R, 3R,1lbR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,1lb-hexahydro-2H-pyrido[2,1a]isoquinolin-2-yl ester.WO 2016/210180 PCT/US2016/039098 00 0)~ 10 z otnn C, Lo 00 0 C 0c