WU, MING DER,吴明德,吳明德,CHENG, MING JEN,郑铭仁,鄭銘仁,LIN, SHIE JEA,林锡杰,林錫杰,CHEN, CHI HUA,陈纪桦,陳紀樺,CHEN, YEN LIN,陈彦霖,陳彥霖,CHEN, HUI PING,陈慧屏,陳慧屏,CHEN, KAI PING,陈凯萍,陳凱萍,YANG, PING SHIN,杨秉勳,楊秉勳,CHEN, SHIOW WEN,陈秀雯
申请号：
TW099147012
公开号：
TWI483726B
申请日:
2010.12.30
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present invention relates to novel pyridine alkaloid compounds of formula (I):or a pharmaceutically acceptable derivative thereof as described in the specification, the process for the preparation of the same, and the composition comprising the same. The uses of a pyridine compound for increasing the activity of PPARγ, for the prevention and/or treatment of a disease or disorder related to insulin resistance, and for the prevention and/or treatment of metabolic syndrome or its complication are also provided. The invention also provides extracts of red yeast-fermented products and their uses for prevention and/or treatment of a disease or disorder related to insulin resistance, such as metabolic syndrome.本發明係關於如本說明書中所述之式(I)之新穎吡啶生物鹼化合物,或其醫藥學上可接受之衍生物、其製備方法、及包含該化合物之組合物。本發明亦提供吡啶化合物用於提高PPARγ活性、預防及/或治療與胰島素抗性相關之疾病或病症、及預防及/或治療代謝症候群或其併發症的用途。本發明亦提供紅麴菌發酵產物之萃取物及其用於預防及/或治療與胰島素抗性相關之疾病或病症(諸如代謝症候群)的用途。(無元件符號說明)
