Masayuki Uchida,Shigeru Yamato,Hajime Ariga,Hirotsugu Uehara,Tomofumi Amano,Keiko Morikubo,Kaori Yoshida
申请号：
US12523010
公开号：
US09675647B2
申请日:
2008.01.17
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present inventors conducted dedicated studies, and as a result discovered that propionic acid bacteria fermentation products have a preventive/therapeutic effect on functional gastrointestinal disorders in in vitro tests and tests using patients with irritable bowel syndrome, and completed the present invention. Specifically, the present inventors discovered, in in vitro tests, that the products have an effect of increasing the intestinal contraction frequency without changing the intestinal contractile force in a distal colon-specific manner. Moreover, effects of improving the defecation condition, general abdominal condition, and health-related QOL in patients with irritable bowel syndrome were also found. Furthermore, propionic acid bacteria fermentation products can be taken in large amounts. Therefore, the propionic acid bacteria fermentation products can be expected to have an effect of preventing/treating functional gastrointestinal disorders safely.
