Children's Hospital and Research Center Oakland;Childrens Hospital and Research Center Oakland
发明人:
Beernink, Peter T.
申请号：
AU2014296027
公开号：
AU2014296027A1
申请日:
2014.08.01
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
Non-naturally occurring factor H binding proteins derived from variant 3 fHbp that can elicit antibodies that are bactericidal for at least one strain of N. meningitidis, and methods of use of such proteins, are provided. In certain embodiments, a non-naturally occurring factor H binding protein (fHbp) derived from a naturally occurring variant 3 fHbp is disclosed. The non-naturally fHbp may include a substitution of the histidine at position 223 of the naturally occurring variant 3 fHbp with an amino acid selected from the group consisting of arginine, lysine, phenylalanine, tyrosine, or tryptophan, wherein the numbering of position 223 is based on the numbering of the mature fHbp ID 1. The non-naturally occurring fHbp may have a lower affinity for human factor H ( fH) than fHbp ID 79.
