GHATTYVENKATAKRISHNA, PAVAN K.,GU, JIAN HUA,GOSS, MONICA MICHELLE,FALLON, JAYMILLE,WONG, LYANNE M.,BRYNCH, STEPHEN ROBERT
申请号：
ARP180101105
公开号：
AR111497A1
申请日:
2018.04.27
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
1. This paper describes the formulation of hydration agents, including human monoclonal diphenyl or other monoclonal anti-Rankl antibodies or some of them, as well as pH characteristics, blocking systems and inhibitors of amino acid polymerization. Formulas for use, such as those for single-purpose containers, single-purpose syringes or glass containers, the use of formulations and articles for the prevention or treatment of diseases are also introduced.There are also related suites. 1. Requirement 1: Underwater pharmaceutical preparations, including (1) a monoclonal active receptor antibody in the human kappa-B nucleon (anti-Rankl) coupler or the solidification of part of the monoclonal active receptor antibody to the antigen, and (2) an inhibitor of amino acid polymerization. 3. Requirement 3: Water-soluble formulations in claims No. 1 or 2, i.e. anti-Rankl antibodies or antigen-cured parts thereof,It includes a light chain variable domain, including a CDR1 sequence in the light chain, including the amino acid sequence listed in SEQ ID 5. Claim 17: Claim 15 or 16 for an underwater drug formulation in which the concentration of the fixed portion of the antibody or its antigen ranges from approximately 100 to 140 mg/ml. 2. Any hydrate in requirements 1, 3 to 19, in which the inhibitor of amino acid polymerization includes an amino acid consisting of a loaded transverse chain.Aromatic or acoustic amino acids. Claim 32: Water-soluble pharmaceutical preparations in claim 31, including hexachlorobenzene or hexachlorobenzene. Requirement 176: A method of preventing skeletal events in patients, including the effective handling of an expression according to requirements 1 to 85 and 172. Claim 177: The method of claim 176 is to select SRE from a group of pathological fractures, bone irradiation, skeletal surgery and spinal cord compression. 2. Claim 178: Method of claim 176 or 177,There, the patient's skeleton metastases to solid tumors. Requirement 179: The method of claim
