Disclosed is a composition comprising: a semipermeable coating； particles of a medicament having an effective average particle size of less than or about 2 um (micrometres) and a surface stabilizer adsorbed on the surface of the medicament particles； and a solubilizing agent. Semi-permeable coatings can be selected from the group consisting of a controlled-porosity microporous coating, a water swellable coating. Surface stabilizer is selected from the group consisting of hydroxypropyl methylcellulose (HPMC), dioctyl sodium sulfosuccinate (DOSS), sodium lauryl sulfate (SLS), hydroxypropyl cellulose, polyvinylpyrrolidone, sodium deoxycholate, block copolymers based on ethylene oxide and propylene oxide, copolymers of vinylpyrrolidone and vinyl acetate, lecithin, polyoxyethylene sorbitan fatty acid esters, albumin, lysozyme, gelatin, macrogol 15 hydroxystearate, tyloxapol, and polyethoxylated castor oil.
