БАРТЕЛЕМИ Филипп (FR),КИАТИ Салим (FR),КАМПЛО Мишель (FR)
申请号：
RU2011153706/15
公开号：
RU2011153706A
申请日:
2010.05.28
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. An I.S. nanoparticle composition comprising a solid core comprising a therapeutic agent and surrounded by at least two lipid layers with different polarity formed by amphiphilic molecules or functional makromolekulami.2. A composition according to claim 1, characterized in that each lipid layer forms a section capable of receiving the therapeutic agent, agent identical to or different from the agent contained in yadre.3. A composition according to claim 1, characterized in that each lipid layer is formed by at least one amphiphilic functional compound of formula (I): wherein X represents an oxygen or sulfur atom or methylene - B represents a purine or pyrimidine base such as uracil , adenine, guanine, cytosine, thymine, hypoxanthine, or derivatives thereof, or as a mono- or bicyclic non-natural heterocyclic base, each cycle of which comprises from 4 to 7 members, optionally substituted - L and L, which are identical or different, represent an atom om hydrogen, an oxycarbonyl group -OC (O) -, thiocarbamate group -OC (S) -NH-, carbonate group -OC (O) -O-, a carbamate group -OC (O) -NH-, an oxygen atom, a phosphate group , phosphonate group or heteroaryl containing from 1 to 4 carbon atoms, substituted or unsubstituted linear or branched, saturated or unsaturated hydrocarbon chain CC or L and Lsovmestno form a ketal group of the formula: or, in addition, Lor Lpredstavlyaet a hydrogen atom and the other radical is a hydroxy group or heteroaryl containing 1 to 4 nitrogen atoms substituted th or unsubstituted linear or branched alkyl CC - r and R, which are identical or Various
