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COMPOSITIONS CONTAINING CYCLIC PEPTIDES AND WAYS OF THEIR APPLICATION
专利权人:
МЕРК ПАТЕНТ ГМБХ (DE)
发明人:
АНЦАЛИ Зохайла (DE),ЙОНЧИК Альфред (DE)
申请号:
RU2010145012/15
公开号:
RU2010145012A
申请日:
2009.04.08
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A topical composition comprising one or more cyclic peptides and one or more carriers suitable for topical application. ! 2. The composition according to claim 1, where the specified cyclic peptide is a homodetic cyclic peptide. ! 3. The composition according to claim 1 or 2, where the specified cyclic peptide includes one or more non-naturally occurring amino acids. ! 4. The composition according to claim 1 or 2, where the specified cyclic peptide consists of 4-30 amino acids selected from the group consisting of naturally occurring amino acids and non-naturally occurring amino acids. ! 5. The composition according to claim 1 or 2, where the specified cyclic peptide includes the sequence Arg-Gly-Asp. ! 6. The composition according to claim 1 or 2, where the specified cyclic peptide is a compound in accordance with formula I! Cycle- (Arg-Gly-Asp-Ω), I! where Ω is an amino acid subsequence comprising one or more amino acids selected from the group consisting of L- and D-forms hPro, Ahds, Aos, Nhdg, Acha, Aib, Acpa, Tle, Gly, Ala, β-Ala, Asn , Asp, Asp (OR), Arg, Cha, Cys, Gln, Glu, His, Ile, Leu, Lys, Lys (Ac), Lys (AcNH2), Lys (AcSH), Met, Nal, Nle, Orn, Phe , 4-Hal-Phe, homo-Phe, Phg, Pro, Pya, Ser, Thr, Tia, Tic, Trp, Tyr or Val,! and their N-alkyl derivatives,! where R is alkyl containing 1-18 carbon atoms,! Hal represents F, Cl, Br, I,! Ac is an alkanoyl containing 1-10 carbon atoms, an aroyl containing 7-11 carbon atoms, or an aralkanoyl containing 8-12 carbon atoms,! and their salts and solvates. ! 7. The composition according to claim 1 or 2, wherein said one or more cyclic peptides include cyclo- (Arg-Gly-Asp-DPhe-Acha) and / or a salt or solvate thereof. ! 8. Composition for topical application, including! i) one or more cyclic peptides as described1. Композиция для местного применения, включающая один или более циклических пептидов и один или более носителей, приемлемых для местного применения. ! 2. Композиция по п.1, где указанный циклический пептид п
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