CAVACO PAULO, ARTUR MANUEL,LOPES PRETO DE ALMEIDA, ANA ARMINDA,DA COSTA NOGUEIRA, EUGENIA SOFIA,FERREIRA CASTRO GOMES, ANDREIA
申请号：
CA2858741
公开号：
CA2858741A1
申请日:
2012.12.07
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention describes the use of conjugated peptide sequences enclosed in liposome membranes. Conjugation can be with a folic acid or an antibody of the folic acid receptor, which is coupled to the N-terminal of the peptide. The presence of these conjugated peptides in liposome formulations allows therapeutic agents and/or imaging agents to be specifically targetted to and subsequently released in cells with expression of folic acid receptors. The thus developed method allies the capacity of liposomes to transport and release drugs with the specific expression of receptors at the surface of cell membranes, allowing transmembrane transport mediated by specific liposomes. It thus can transport both hydrophobic and hydrophilic therapeutic and/or imaging agents inside the liposome. The therapeutic agents can be pharmacological compounds - active principles - or small interfering RNAs (siRNAs) specific to defined target genes.
