TRABANCO SUÁREZ Andrés Avelino,GIJSEN HENRICUS JACOBUS MARIA,SURKYN MICHEL,PROKOPCOVÁ HANA
申请号：
IN1153/MUMNP/2014
公开号：
IN2014MN01153A
申请日:
2014.06.10
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The invention relates to novel 6 difluoromethyl 5 6 dihydro 2H [l 4]oxazin 3 amine derivatives as inhibitors of beta secretase also known as beta site amyloid cleaving enzyme BACE BACE1 Asp2 or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds to processes for preparing such compounds and compositions and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta secretase is involved such as Alzheimer s disease (AD) mild cognitive impairment senility dementia dementia with Lewy bodies cerebral amyloid angiopathy multi infarct dementia Down s syndrome dementia associated with stroke dementia associated with Parkinson s disease and dementia associated with beta amyloid.
