DR. CHAVA SATYANARAYANA,DR. GORANTLA SEETA RAMANJANEYULU,DR. GINJUPALLI PRASANNA BHAGYA LAKSHMI
申请号：
IN957/CHE/2005
公开号：
IN262831B
申请日:
2005.07.19
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention encompasses a method for the preparation of Telmisartan comprises, through Telmisartan dihydrochloride comprises i) Condensing 4-Methyl-2-n-propyl-lH-benzimidazole-6-carboxylic acid with N-Methyl-O-phenylenediamine dihydrochloride to yields 4-methyl-6 (1-methyl benzimidazol-2-yl)-2-n-propyl lH-benzimidazole ii) Treating 4-methyl-6-( 1 -methyl benzimidazol-2-yl)- 2-n-propyl-1 H-benzimidazole with 4" -(bromomethyl)-2-biphenyl-2-carboxylate in presence of a base in an organic solvent and isolating the ester as acid addition salt iii) Converting ester acid addition salt to Telmisartan dihydrochloride and iv) Converting Telmisartan dihydrochloride to Telmisartan.
