This document provides useful compounds and methods of use as persistent organic pollutant inhibitor 4. Fgf4 is defined as the receptor of Fgf4. 1. Claim 1: a formula compound (1),where: R³ is selected from the group consisting of: C₁₋₆ alkyl,C₁₋₆-alkoxy-C₁₋₆-alkyl,NR¹⁰R¹¹-C₁₋₆ alkyl,heterocyclyl-R¹⁰-C₁₋₆-alkyl,aryl-R¹⁰-C₁₋₆ alkyl,And shaped-r18304e-tar c832c831832626,wherein R¹⁰ and R¹¹ are each independently selected from the group consisting of: hydrogen and C₁₋₆ alkyl；E selected from the following groups: NR: C (o) Cr: 830808 = chrris83099；y -NR C (O) C CRR1 m3 is selected from a group consisting of hydrogen and methyl, R1 83088 and R1 83099； each part is selected independently from the group consisting of hydrogen, methyl, fluorine and chlorine； R1 2 is selected from the group consisting of hydrogen, halogen, c833183 coke oil；C₁₋₆ alkoxy,hydroxyalkyl C₁₋₆,hydroxyalkoxy C₁₋₆,C₁₋₆-alkoxy-C₁₋₆-alkoxy,C₁₋₆-alkoxy-C₁₋₆-alkyl,Isopropene-r8309； - r8310；-C (o) isocyclohexane-r8309； r8310a；R8309；]8309； 8310；NR⁵R⁶-C₁₋₆ alkyl,-C (O) NR Rand NR⁵R⁶-C₁₋₆ alkyloxy,wherein R⁵ and R⁶ are each independently selected from the group consisting of hydrogen, C₁₋₆ alkyl,hydroxyalkyl C₁₋₆,C₁₋₆ aminoalkyl,-C (O) C₁₋₆ alkyl and C₁₋₆sulfonyl alkyl； and R¹ is phenyl, wherein said phenyl is substituted 2, 3, or 4 times with independently selected halo or C₁₋₆ alkoxy； or a pharmaceutically acceptable salt thereof.En el presente documento se proporcionan compuestos útiles como inhibidores de FGFR4, así como sus métodos de uso. FGFR4 definido como Receptor del Factor de Crecimiento de Fibroblastos 4. Reivindicación 1: Un compuesto de fórmula (1), en donde: R³ se selecciona del grupo que consta de: alquilo C₁₋₆, alcoxi C₁₋₆-alquilo C₁₋₆, NR¹⁰R¹¹-alquilo C₁₋₆, heterociclilo-R¹⁰-alquilo C₁₋₆, arilo-R¹⁰-alquilo C₁₋₆, y heteroarilo-R¹⁰-alquilo C₁₋₆, en donde R¹⁰ y R¹¹ cada uno se selecciona de modo independiente del grupo que consta de: hidrógeno y alquilo C₁₋₆； E se selecciona del grupo que const
