Alexander Schmidt,Katharina Veltman,Christoph Cichon
申请号：
US14238443
公开号：
US20140199402A1
申请日:
2012.08.09
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a nucleic acid molecule of up to 150 nucleotides comprising consecutively from 5′ to 3′ (a) a first part whose sequence is between 50% and 100% complementary to the sequence AAAAGCUGGGUUGAGAGGGCGA； (b) a second part capable of forming a loop between the first and the third part； and (c) a third part comprising or consisting of the sequence AAAAGCUGGGUUGAGAGGGCGA； for use as a medicament. The present invention further relates to a nucleic acid molecule of up to 25 nucleotides comprising the sequence AAAAGCUGGGUUGAGAGGGCGA, for use as a medicament. In another aspect, the present invention relates to a composition comprising at least one mature miRNA selected from the group consisting of hsa-miR-320a, ptr-miR-320a, ppy-miR-320a, bta-miR-320, cfa-miR-320, mmu-miR-320, rno-miR-320, and mml-miR-320, and/or one or more mir-RNA precursor(s) thereof, for use as a medicament.
