MENNE, Torkil,SELMER, Johan,LANGE, Jesper,GEORGIOU, Michelle,WHEELER, Derek,EVANS, David
申请号：
EP17812796
公开号：
EP3471720A4
申请日:
2017.06.16
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
There is provided a topical formulation comprising a nucleophile, such as amino acids and most polypeptides and/or a derivative thereof, for use in the treatment or prevention of itchy dry skin caused by urea, such as in uremic pruritus, of a subject. The amino acid may be histidine and the derivative may be a histidine degradation product, a peptide of histidine, a peptide of histidine and one or more additional amino acids, and a pharmaceutically-acceptable salt of histidine.
