BEUSKER, Patrick Henry,COUMANS, Rudy Gerardus Elisabeth,ELGERSMA, Ronald Christiaan,MENGE, Wiro Michaël Petrus Bernardus,JOOSTEN, Johannes Albertus Frederikus,SPIJKER, Henri Johannes,DE GROOT, Francis
申请号：
ES09748515
公开号：
ES2647317T3
申请日:
2009.11.03
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formulas (I) or (II): ** Formula ** or a pharmaceutically acceptable salt, hydrate or solvate thereof, wherein DB is a DNA binding moiety and is ** Formula ** R1 it is a halide (fluoride, chloride, bromide and iodide), azide, a sulfonate (for example, an optionally substituted C1-6 alkanesulfonate, such as methanesulfonate and trifluoromethanesulfonate, or an optionally substituted C7-12 alkylbenzenesulfonate, such as p-toluenesulfonate) , Succinimide N-oxide, p-nitrophenoxide, pentafluorophenoxide, tetrafluorophenoxide, a carboxylate and aminocarboxylate (carbamate) or an alkoxycarboxylate (carbonate)； R2, R2 ', R3, R3', R4, R4 ', R12 and R19 are independently selected from H, OH, SH, NH2, N3, NO2, NO, CF3, CN, C (O) NH2, C (O) H, C (O) OH, halogen, Ra, SRa, S (O) Ra, S (O) 2Ra, S (O) ORa, S (O) 2ORa, OS (O) Ra, OS (O) 2Ra, OS (O) ORa, OS (O) 2ORa, ORa, NHRa, N (Ra) Rb, + N (Ra) (Rb) Rc, P (O) (ORa) (ORb), OP (O) (ORa) (ORb), SiRaRbRc, C (O) Ra, C (O) ORa, C (O) N (Ra) Rb, OC (O) Ra, OC (O) ORa, OC (O) N (Ra) Rb, N (Ra) C (O) Rb, N (Ra) C (O) ORb and N (Ra) C (O) N (Rb) Rc, in which Ra, Rb and Rc are independently selected from H and C1 alkyl -3 or optionally substituted C1-3 heteroalkyl, or R3 + R3 'and / or R4 + R4' are independently selected from>； = O,>； = S,>； = NOR18,>； = C (R18) R18 'and>； = NR18 , R18 and R18 'independently selected from H and optionally substituted C1-3 alkyl, two or more of R2, R2', R3, R3 ', R4, R4' and R12 being optionally linked by one or more bonds to form one or more optionally substituted carbocycles and / or heterocycles； X2 is selected from O, C (R14) (R14 ') and NR14', in which R14 and R14 'have the same meaning as defined for R7 and are independently selected, or R14' and R7 'are absent, giving as a result a double bond between the atoms designated to carry R7 'and R14'； R5, R5 ', R6, R6', R7 and R7 'are independently selected from H, OH, SH, NH2, N3, NO2, NO, CF3, CN, C (O) NH2, C (O) H, C ( O) OH, halog
