THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMANSERVICES
发明人:
申请号：
EP05018103.1
公开号：
EP1630229B1
申请日:
1995.04.21
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognose a mammal afflicted with melanoma or metastata melanoma. This invention also provides immunogenic peptides derived from the MART-1 melanoma antigen and a second melanoma antigen designated gp100. This invention further provides immunogenic peptides derived from the MART-1 melanoma antigen or gp100 antigen which have been modified to enhance their immunogenicity. The proteins and peptides provided can serve as an immunogen or vaccine to prevent or treat melanoma.
