Mi Ock LEE,Hyeung Geun PARK,Mi-La CHO,Yong-Hyun HAN,Hyeon-Ji KIM,Jin-Sil PARK
申请号：
US15752079
公开号：
US20180235912A1
申请日:
2016.08.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a novel use of a thiourea derivative and, more specifically, to a pharmaceutical composition for preventing or treating autoimmune diseases comprising a thiourea derivative as an active ingredient. The thiourea derivative according to the present invention can inhibit the transcription of inflammatory genes such as TNF-α, IL-1β, NOS2 and IL-6, and also can inhibit the activity or production of Th17 and increase the activity or production of a regulatory T cell (Treg). Thus, it is expected that the thiourea derivative may be usefully used in a pharmaceutical composition, a health food composition, etc. for the prevention, improvement or treatment of various autoimmune diseases including rheumatoid arthritis.
