Variants derived from ActRIIB and uses therefor

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专利权人:

Acceleron Pharma Inc.

发明人:

Kumar, Ravindra,Knopf, John,Seehra, Jasbir

申请号：

AU2008214375

公开号：

AU2008214375B2

申请日:

2008.02.04

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

In certain aspects, the present invention provides compositions and methodsfor modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage,muscle, fat, and/or neuronal tissue. The present invention also provides methodsof screening compounds that modulate activity of an ActRIIB protein and/or anActRIIB ligand. The compositions and methods provided herein are useful in treatingdiseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIBligand.

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