CHILDREN'S MEDICAL CENTER CORPORATION;HELLSTROEM, ANN
发明人:
SMITH, LOIS,HELLSTROEM, ANN
申请号：
CA2429615
公开号：
CA2429615C
申请日:
2001.11.13
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
In one aspect of the present invention there is provided a method fordetermining the risk of developing a complication of preterm birth in apatient born before 40 weeks of gestation or weighing 10 % less than theaverage for the patient's gestational age. The method involves measuring serumIGF-I and/or IGF-I binding protein levels after birth of the patient to obtainan IGF-I or IGF binding protein level； and correlating said IGF-I or IGF-Ibinding protein level with an in utero baseline level of IGF-I binding proteinbased on gestational age matched mean levels in utero, wherein an IGF-I or IGF-I binding protein level below the mean gestational age in utero levelindicates the patient is at an increased risk of developing a complication ofpreterm birth. The complications of preterm birth include retinopathy ofprematurity, developmental delay, mental retardation, bronchopulmonarydysplasia, and intraventricular hemorrhage. Methods for treating/preventingcomplications of preterm birth are also provided.
