A biopsy device for harvesting tissue samples from a suspect tissue mass in a body of a living being, e.g. in percutaneous aspiration biopsy, includes a hollow needle and a sample-receiving device, which is movable in the hollow needle. A first user-operable firing mechanism is provided for causing the hollow needle and the sample-receiving device to be substantially simultaneously displaced in a distal direction, so as to penetrate body tissue at or near the suspect tissue mass. A second user-operable firing mechanism may cause the hollow needle solely to be longitudinally displaced in a distal direction from a position, in which the sample-receiving device projects from the distal end of the hollow needle, to a position, in which the hollow needle essentially accommodates the sample-receiving device, so as to sever the tissue sample from remaining body tissue at the harvesting site.
