BLUME THORSTEN,SCHMEES NORBERT,WINTERMANTEL TIM,HELDMANN DIETER,OTTO CHRISTIANE,KUHNKE JOACHIM
申请号：
ZA201101445
公开号：
ZA201101445B
申请日:
2011.02.23
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
The present invention is directed to novel pyrazolo-estrien and triazolo-estrien-derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by an estrogen receptor such as hot flashes, vaginal dryness, osteopenia, osteoporosis, hyperlipidemia, loss of cognitive function, degenerative brain diseases, cardiovascular diseases, cerebrovascular diseases, hormone sensitive cancers and hyperplasia (in tissues including breast, endometrium, and cervix in women and prostate in men), endometriosis, uterine fibroids, osteoarthritis； and as contraceptive agents either alone or in combination with a progestogen or progestogen antagonist. The compounds of the invention are selective estrogen receptor modulators.
