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Pyridazine derivatives for use in the prevention or treatment of an ataxic disorder
专利权人:
Takeda Pharmaceutical Company Limited
发明人:
ALMOND, Sarah
申请号:
ES15709324
公开号:
ES2676905T3
申请日:
2015.03.06
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of formula (I), or a pharmaceutically acceptable salt thereof, ** Formula ** in which R1 represents a hydrogen or fluorine atom or a trifluoromethyl group: R2 represents a group -X-Y-R3; X and Y each independently represent a link or a group -C (O), -S (O) n, -C (O) NR4, -S (O) 2NR4, - NR4, or -CR4R5- provided that X e And they cannot simultaneously represent a link and as long as X and Y are both different from a link, then at least one of X and Y represents -CR4R5-; n is 0, 1 or 2; each R4 independently represents a hydrogen atom or a C1-C6 alkyl or C1-C6 haloalkyl group; each R5 independently represents a hydrogen atom, a C1-C6 alkyl or C1-C6 haloalkyl group or>; = CH-; R3 represents a saturated or unsaturated carbocyclic or heterocyclic ring system of 3 to 10 members, the same ring system being optionally substituted with at least one substituent selected from halogen, hydroxyl, cyano, oxo, C1-C6 alkyl, C2-C6 alkenyl , C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 alkylcarbonyl, C1-C6 alkylcarbonyloxy, C1-C6 alkoxycarbonyl , amino, -CON (R6) 2, C1-C6 alkylamino, di- (C1-C6 alkyl) amino, C3-C6 cycloalkyl, C3-C6 cycloalkoxy, C1-C6 cycloalkylmethyl, - [O] p- (CH2) qO -R7 and a saturated or unsaturated 4 to 6 membered heterocyclic ring (optionally substituted with at least one substituent selected from C1-C4 alkyl and C1-C4 alkoxy); each R6 independently represents a hydrogen atom or a C1-C6 alkyl group; p is 0 or 1; q is 1, 2, 3 or 4; and R7 represents a C1-C6 alkyl group; for use in the prevention or treatment of an ataxic disorder.Un compuesto de fórmula (I), o una sal farmacéuticamente aceptable del mismo, **Fórmula** en la que R1 representa un átomo de hidrógeno o flúor o un grupo trifluorometilo: R2 representa un grupo -X-Y-R3; X e Y representan cada uno independientemente un enlace o un grupo -C(O), -S(O)n, -C(O)NR4, -S(O)2NR4, - NR4, o -CR4R5- siempre que X e
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