SMITH, ROBIN Y.,GLICKSMAN, MARCIE A.,CORNIVELLI, LIZBETH
申请号：
CA3093370
公开号：
CA3093370A1
申请日:
2019.03.05
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Presented herein are personalized compositions comprising iPSCs and/or iPSC-derived cells (cells) and methods of producing personalized compositions suitable for various therapies, including chondrogenesis therapies, to be administered to an individual or a group of individuals. The cells and/or cell lines, and any compositions derived therefrom, are identified as compatible with a specific individual or specific group of individuals using an identification of a cell type indicative of compatibility such as an HLA match. The compatible cells are then used to derive "personalized" compositions, wherein the "personalized" compositions comprise one or more cell-secreted molecules suitable for therapy. It is found herein that a composition comprising one or more iPSC-derived MSCs, iPSC-derived chondrocytes, and iPSC-derived chondrons may provide improved treatment efficacy than would be offered by bone marrow-MSCs (BM-MSCs) or compositions comprising BM-MSCs.
