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fgf receptor agonist dimeric compounds (fgfr), process for their preparation and therapeutic use thereof
专利权人:
SANOFI
发明人:
ALEXANDRE BENAZET,NATHALIE GUILLO
申请号:
BR112014016126
公开号:
BR112014016126A8
申请日:
2012.12.26
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
fgf receptor (fgfr) agonist dimeric compounds, process for its preparation and therapeutic use thereof sanofi abstract the invention relates to novel heterocyclic compounds which are pyrazolopyridine derivatives which induce fgfr dimerization, having the general formula: m1-l-m2 in which m1 and m2, which may be identical or different, each represent, independently of one another, a monomer unit m and l represents a linker group which links m1 and m2 covalently with the monomer unit which follows: process for the preparation of this and therapeutic use thereof. Patent Abstract: "FGF receptor agonist dimeric compounds (FGFR), process for preparing them and therapeutic use thereof". The invention relates to novel heterocyclic compounds which are pyrazolopyridine derivatives which induce fgfr dimerization, having the general formula: wherein m1 and m2, which may be identical or different, each independently represents one of the two. another, a mobile monomer unit represents a linker group that connects m1 and m2 covalently with the following monomer unit (formula m). process for their preparation and therapeutic use thereof.fgf receptor (fgfr) agonist dimeric compounds, process for the preparation thereof and therapeutic use thereof sanofi abstract the invention relates to novel heterocyclic compounds which are pyrazolopyridine derivatives that induce fgfr dimerization, having the general formula: m1-l-m2 in which m1 and m2, which may be identical or different, each represent, independently of one another, a monomer unit m and l represents a linker group which links m1 and m2 covalently with the monomer unit which follows: process for the preparation thereof and therapeutic use thereof. resumo patente de invenção: "compostos diméricos agonistas de receptor de fgf (fgfr), processo para a preparação de dos mesmos e uso terapêutico dos mesmos". a invenção se refere aos novos compostos heterocíclicos que são derivados de pirazolopiridina que induzem à dimerização de fgfr,
来源网站:
中国工程科技知识中心
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