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ENGINEERED T CELLS AND USES THEREFOR
专利权人:
Pieris Pharmaceuticals GmbH
发明人:
Marlon Hinner
申请号:
US15542915
公开号:
US20180021418A1
申请日:
2016.01.11
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Lipocalin muteins specific to a predetermined antigen can be transduced into a T cell to bring therapeutic benefits to patients in need. In one example, a lipocalin mutein specific to a predetermined antigen (e.g., a target differentially expressed on the surface of a tumor cell) can be transduced into a T cell membrane to serve as an antigen receptor, offering benefits over conventionally deployed antibody-derived protein moieties such as a single chain variable fragment (scFv). Benefits include a more stable structure, leading to superior target engagement, for example. Further, lipocalin muteins specific to a predetermined antigen (e.g. an immunomodulatory target such as an immune checkpoint or costimulatory molecule) can be transduced into a T cell for secretion thereby, bringing an added therapeutic benefit. Specific examples of such modified T cells and methods of making and using the same are provided herein.
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中国工程科技知识中心
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