INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;AURIS MEDICAL AG
发明人:
Matthieu Guitton,Jean-Luc Puel,Remy Pujol,Jerome Ruel,Jing Wang
申请号：
US14448999
公开号：
US09072662B2
申请日:
2014.07.31
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention relates to methods for the prevention and/or treatment of tinnitus induced by cochlear excitotoxicity. In these methods, a pharmaceutical composition comprising an NMDA receptor antagonist is administered to an individual in need of such treatment by appropriate devices and/or formulations for local administration to the inner ear. The tinnitus to be prevented and/or treated may be provoked by acoustic trauma, presbycusis, ischemia, anoxia, treatment with one or more ototoxic medications, sudden deafness, or other cochlear excitotoxic-inducing occurrence. The invention also relates to method for the identification of compounds effective in the treatment and prevention of tinnitus by a novel screening method incorporating an electrophysiological test method.
