A vitrectomy probe includes a hand-graspable body and an external tube extending from the hand-graspable body and sized to penetrate an eye of a patient during an ocular surgery. In an aspect, the external tube includes a closed end and a plurality of ports sized to receive vitreous material. In another aspect, an internal tube has a first cutting edge facing in a proximal direction and a second cutting edge facing in a distal direction. The first cutting edge oscillates across the port of the external tube to cut tissue in the port with the first cutting edge when the internal tube moves in the proximal direction and to cut tissue in the port with the second cutting edge when the internal tube moves in the distal direction.
