Croma Pharma GmbH;ThioMatrix Forschungs- und Beratungs GmbH
发明人:
LEIERER, Johannes
申请号：
EP10760673.3
公开号：
EP2482852B1
申请日:
2010.09.29
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Because of the formation of disulfide bridges with mucus glycoproteins, the mucoadhesive properties of polymeric compounds can be significantly improved by the covalent attachment of thiol substructures to them. By the transformation of free thiol groups on such polymers in disulfides with mercaptonicotinamides or mercaptopyridoxins these thiol groups become comparatively more reactive resulting in significantly improved mucoadhesive properties. Furthermore, polymers exhibiting disulfide partial structures with mercaptonicotinamides or mercaptopyridoxins do not need to be protected against oxidation. In addition, they show comparatively higher permeation enhancing properties.
