BONNERT, ROGER VICTOR,MCINALLY, THOMAS,THOM, STEPHEN
申请号：
ES08718797
公开号：
ES2457316T3
申请日:
2008.03.19
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
An adenine compound represented by Formula (I) ** Formula ** wherein R1 represents hydrogen, hydroxy, C1-C6 alkoxy, C2-C5 alkoxycarbonyl, or a C6-C10 aryl, C5-C10 heteroaryl or C3- cycloalkyl group C8, wherein any available carbon atom in each group is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C2- alkoxycarbonyl C5, amino, mono- or di-C1-C6 alkylamino； Y1 represents a single bond or C1-C6 alkylene； X1 represents a single bond or an oxygen or sulfur, sulfinyl, sulfonyl or NR4 atom where R4 is hydrogen or C1-6 alkyl； with the proviso that when R1 is hydroxy, C1-6 alkoxy or C2-C5 alkoxycarbonyl and X1 is oxygen, Y1 is different from a single bond； L is a straight or branched C1-6 alkylene group or bond, where up to 3 carbon atoms within the alkylene group can be substituted by oxygen, sulfur, SO, SO2, carbonyl or NR5, where R5 is hydrogen or C1 alkyl -6； and R2 is pyrrolidine, piperidine, morpholine, thiomorpholine, thiomorpholine-1-oxide or thiomorpholine-1,1-dioxide； with the proviso that when R1 represents a hydrogen atom, Y1 represents a straight C4 alkylene group, X1 represents an oxygen atom and L represents a C2 alkylene group, then R2 does not represent a 2-piperidinyl group； or a pharmaceutically acceptable salt thereof.Un compuesto de adenina representado por la Fórmula (I) **Fórmula** en donde R1 representa hidrógeno, hidroxilo, alcoxi C1-C6, alcoxicarbonilo C2-C5, o un arilo C6-C10, heteroarilo C5-C10 o grupo cicloalquilo C3-C8, en donde cualquier átomo de carbono disponible en cada grupo es sustituido opcionalmente por uno o más sustituyentes seleccionado independientemente de halógeno, hidroxilo , alquilo C1-C6, haloalquilo C1-C6, alcoxi C1-C6, haloalcoxi C1-C6, alcoxicarbonilo C2-C5, amino , mono-o di-alquilamino C1-C6； Y1 representa un enlace sencillo o alquileno C1-C6； X1 representa un enlace sencillo o un átomo de oxígeno o de azufre,
